A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury. — PubMed · 2023 · Journal Article
- Neuroprotective Effects of Microglial Membrane-Derived Biomimetic Particles for Spinal Cord Injury. — PubMed · 2023 · Journal Article
- A Review of Strategies Associated with Surgical Decompression in Traumatic Spinal Cord Injury. — PubMed · 2023 · Review
- Bioactive role of vitamins as a key modulator of oxidative stress, cellular damage and comorbidities associated with spinal cord injury (SCI). — PubMed · 2023 · Review
- Targeting Mitochondrial Oxidative Stress: Potential Neuroprotective Therapy for Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Tibolone Improves Locomotor Function in a Rat Model of Spinal Cord Injury by Modulating Apoptosis and Autophagy. — PubMed · 2023 · Journal Article
- Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns. — PubMed · 2023 · Journal Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models. — PubMed · 2023 · Journal Article
- The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke. — PubMed · 2023 · Journal Article
- Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis. — PubMed · 2023 · Journal Article
- Use of Cells, Supplements, and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update. — PubMed · 2023 · Journal Article
- Letter to the Editor. Methylprednisolone following acute traumatic spinal cord injury. — PubMed · 2023 · Letter
- Riluzole in Spinal Cord Injury Study (RISCIS)-Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial. — PubMed · 2023 · Randomized Controlled Trial
- Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. — PubMed · 2023 · Randomized Controlled Trial
- The NF-κB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Supramolecular assemblies with spatio-temporal sequential drug delivery capability treat spinal cord injury via neuroprotection and immunoregulation. — PubMed · 2023 · Journal Article
- Transplantation of Wnt4-modified neural stem cells mediate M2 polarization to improve inflammatory micro-environment of spinal cord injury. — PubMed · 2023 · Journal Article
- Growth factors and their peptide mimetics for treatment of traumatic brain injury. — PubMed · 2023 · Journal Article
- The progress and controversies regarding steroid use in acute spinal cord injury. — PubMed · 2023 · Review
- Therapeutic potential of natural compounds from herbs and nutraceuticals in spinal cord injury: Regulation of the mTOR signaling pathway. — PubMed · 2023 · Journal Article
- The Role of Aquaporins in Spinal Cord Injury. — PubMed · 2023 · Journal Article
- A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities. — PubMed · 2023 · Journal Article
- Neuroprotective Roles of Apelin-13 in Neurological Diseases. — PubMed · 2023 · Journal Article
- Practice of neuromonitoring in open and endovascular thoracoabdominal aortic repair-an international expert-based modified Delphi consensus study. — PubMed · 2023 · Journal Article
- Safe Reversal of Motor and Sensory Deficits by Repeated High Doses of Mesenchymal Stem Cells in a Patient with Chronic Complete Spinal Cord Injury. — PubMed · 2023 · Case Reports
- Ca(v) 1.3-selective inhibitors of voltage-gated L-type Ca(2+) channels: Fact or (still) fiction? — PubMed · 2023 · Journal Article
- Protecting the injured central nervous system: Do anesthesia or hypothermia ameliorate secondary injury? — PubMed · 2023 · Systematic Review
- Survival Model of Thoracic Contusion Spinal Cord Injury in the Domestic Pig. — PubMed · 2023 · Journal Article
- The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases. — PubMed · 2023 · Review
- Advances in molecular therapies for targeting pathophysiology in spinal cord injury. — PubMed · 2023 · Review
- A mechanistic overview of spinal cord injury, oxidative DNA damage repair and neuroprotective therapies. — PubMed · 2023 · Journal Article
- Inhibition of A1 Astrocytes and Activation of A2 Astrocytes for the Treatment of Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Multiple mechanisms of curcumin targeting spinal cord injury. — PubMed · 2023 · Journal Article
- Predicting the Role of Preoperative Intramedullary Lesion Length and Early Decompressive Surgery in ASIA Impairment Scale Grade Improvement Following Subaxial Traumatic Cervical Spinal Cord Injury. — PubMed · 2023 · Journal Article
- The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury. — PubMed · 2023 · Journal Article
- The role of mitochondrial energy metabolism in neuroprotection and axonal regeneration after spinal cord injury. — PubMed · 2023 · Journal Article
- Clinical Trials Targeting Secondary Damage after Traumatic Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Glutathione in the Pons Is Associated With Clinical Status Improvements in Subacute Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Interleukin-4 as a therapeutic target. — PubMed · 2023 · Journal Article
- Motor rehabilitation as a therapeutic tool for spinal cord injury: New perspectives in immunomodulation. — PubMed · 2023 · Review
- Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Surgical Decompression of Traumatic Cervical Spinal Cord Injury: A Pilot Study Comparing Real-Time Intraoperative Ultrasound After Laminectomy With Postoperative MRI and CT Myelography. — PubMed · 2023 · Journal Article
- The Importance of Using Exosome-Loaded miRNA for the Treatment of Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Zinc Promotes Spinal Cord Injury Recovery by Blocking the Activation of NLRP3 Inflammasome Through SIRT3-Mediated Autophagy. — PubMed · 2023 · Journal Article
- Current Concepts of Biomaterial Scaffolds and Regenerative Therapy for Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Specific Blood RNA Profiles in Individuals with Acute Spinal Cord Injury as Compared with Trauma Controls. — PubMed · 2023 · Journal Article
- Immune response following traumatic spinal cord injury: Pathophysiology and therapies. — PubMed · 2023 · Journal Article
- The role of immune cells and associated immunological factors in the immune response to spinal cord injury. — PubMed · 2023 · Journal Article
- Co-Administration of Nanowired Monoclonal Antibodies to Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Alpha Together with Antioxidant H-290/51 Reduces SiO(2) Nanoparticles-Induced Exacerbation of Pathophysiology of Spinal Cord Trauma. — PubMed · 2023 · Review
- Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury. — PubMed · 2023 · Journal Article
- Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review. — PubMed · 2023 · Review
- The Use of Campenot Trichambers for the Study of Peripheral Neuronal Growth and Survival in Presence of Thrombotic Factors and Serpins. — PubMed · 2023 · Journal Article
- Molecular Mechanisms and Clinical Application of Multipotent Stem Cells for Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds. — PubMed · 2022 · Journal Article
- Left Subclavian Artery Sacrifice in Acute Aortic Dissection Repair using the Frozen Elephant Trunk. — PubMed · 2022 · Journal Article
- Proposal of a Management Algorithm to Predict the Need for Expansion Duraplasty in American Spinal Injury Association Impairment Scale Grades A-C Traumatic Cervical Spinal Cord Injury Patients. — PubMed · 2022 · Journal Article
- The Neuroprotection Effects of Exosome in Central Nervous System Injuries: a New Target for Therapeutic Intervention. — PubMed · 2022 · Journal Article
- Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury. — PubMed · 2022 · Editorial
- Mitochondrial regulatory mechanisms in spinal cord injury: A narrative review. — PubMed · 2022 · Review
- Pathophysiology and Therapeutic Approaches for Spinal Cord Injury. — PubMed · 2022 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 6 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1230843 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 3744 · this programme has 3744 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])