A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. — PubMed · 2000 · Journal Article
- Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats. — PubMed · 2000 · Journal Article
- Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury. — PubMed · 2000 · Comparative Study
- Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. — PubMed · 2000 · Comparative Study
- Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats. — PubMed · 2000 · Comparative Study
- Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone. — PubMed · 2000 · Journal Article
- Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. — PubMed · 2000 · Journal Article
- The early protective effects of L-arginine and Ng-nitro-L-arginine methyl ester after experimental acute spinal cord injury. A light and electron microscopic study. — PubMed · 2000 · Comparative Study
- Increased neurosteroids synthesis after brain and spinal cord injury in rats. — PubMed · 2000 · Journal Article
- Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury. — PubMed · 2000 · Journal Article
- Action of locally administered NMDA and AMPA/kainate receptor antagonists in spinal cord injury. — PubMed · 2000 · Journal Article
- Lazaroid reduces production of IL-8 and IL-1 receptor antagonist in ischemic spinal cord injury. — PubMed · 2000 · Journal Article
- Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection. — PubMed · 2000 · Journal Article
- Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration. — PubMed · 2000 · Comparative Study
- Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat. — PubMed · 2000 · Journal Article
- Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. — PubMed · 2000 · Journal Article
- Motor function changes in the rat following severe spinal cord injury. Does treatment with moderate systemic hypothermia improve functional outcome? — PubMed · 2000 · Journal Article
- Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: dose-window and time-window effects. — PubMed · 2000 · Journal Article
- Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat. — PubMed · 2000 · Journal Article
- A word of caution in extrapolating the riluzole spinal cord injury protective effects obtained in a rabbit model under ketamine anesthesia. — PubMed · 1999 · Comment
- Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. — PubMed · 1999 · Journal Article
- Effects of MK801 on evoked potentials, spinal cord blood flow and cord edema in acute spinal cord injury in rats. — PubMed · 1999 · Journal Article
- Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. — PubMed · 1999 · Journal Article
- NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. — PubMed · 1999 · Journal Article
- Intrathecal adenosine does not relieve allodynia-like behavior in spinally injured rats. — PubMed · 1999 · Journal Article
- Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury. — PubMed · 1999 · Comparative Study
- Glucocorticoid regulation of motoneuronal parameters in rats with spinal cord injury. — PubMed · 1999 · Journal Article
- Is indomethacin harmful in spinal cord injury treatment? An experimental study. — PubMed · 1999 · Journal Article
- Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. — PubMed · 1999 · Journal Article
- Basic fibroblast growth factor (bFGF) enhances tissue sparing and functional recovery following moderate spinal cord injury. — PubMed · 1999 · Journal Article
- [The early protective effects of basic fibroblast growth factor on acute spinal cord injury in rats]. — PubMed · 1999 · English Abstract
- Spinal cord injury in small animals 2. Current and future options for therapy. — PubMed · 1999 · Comment
- Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. — PubMed · 1999 · Journal Article
- Therapeutic time window for methylprednisolone in spinal cord injured rat. — PubMed · 1999 · Journal Article
- Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. — PubMed · 1999 · Journal Article
- Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist. — PubMed · 1999 · Journal Article
- Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat. — PubMed · 1999 · Journal Article
- Long-term effects of methylprednisolone following transection of adult rat spinal cord. — PubMed · 1999 · Journal Article
- Neuroprotective effect of magnesium on lipid peroxidation and axonal function after experimental spinal cord injury. — PubMed · 1999 · Journal Article
- Neuroprotective effects of basic fibroblast growth factor following spinal cord contusion injury in the rat. — PubMed · 1999 · Journal Article
- Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. — PubMed · 1999 · Comparative Study
- Changes in ornithine decarboxylase activity and putrescine concentrations after spinal cord compression injury in the rat. — PubMed · 1999 · Journal Article
- Does loss of gray- and white-matter contrast in injured spinal cord signify secondary injury? In vivo longitudinal MRI studies. — PubMed · 1999 · Journal Article
- Effect of treatment with 21-aminosteroid U-74389G and glucocorticoid steroid methylprednisolone on somatosensory evoked potentials in rat spinal cord during mild compression. — PubMed · 1999 · Journal Article
- A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. — PubMed · 1999 · Journal Article
- Calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury. — PubMed · 1999 · Journal Article
- Neuroprotective effects of riluzole in neurotrauma models: a review. — PubMed · 1999 · Journal Article
- Trophic factor modulation of c-Jun expression in supraspinal neurons after chronic spinal cord injury. — PubMed · 1998 · Journal Article
- Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury. — PubMed · 1998 · Journal Article
- Systemic hypothermia after spinal cord compression injury in the rat: does recorded temperature in accessible organs reflect the intramedullary temperature in the spinal cord? — PubMed · 1998 · Journal Article
- Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury. — PubMed · 1998 · Journal Article
- [Glutamate neurotoxicity during spinal cord ischemia--neuroprotective effects of glutamate receptor antagonists]. — PubMed · 1998 · English Abstract
- Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats. — PubMed · 1998 · Journal Article
- Motoneurotrophins derived from limb buds protect the motoneurons in anterior spinal cord after nerve injury and promote nerve regeneration. — PubMed · 1998 · Journal Article
- Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest. — PubMed · 1998 · Journal Article
- Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. — PubMed · 1998 · Journal Article
- Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. — PubMed · 1998 · Journal Article
- Traumatic spinal cord injury induces nuclear factor-kappaB activation. — PubMed · 1998 · Journal Article
- Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury. — PubMed · 1998 · Journal Article
- [Glutamate neurotoxicity during spinal cord ischemia--the neuroprotective effects of adenosine]. — PubMed · 1998 · English Abstract
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])