A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury. — PubMed · 1998 · Journal Article
- Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat. — PubMed · 1998 · Journal Article
- Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers. — PubMed · 1997 · Journal Article
- BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. — PubMed · 1997 · Journal Article
- Quantitative analysis of acute axonal pathology in experimental spinal cord contusion. — PubMed · 1997 · Journal Article
- Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures. — PubMed · 1997 · Journal Article
- A non-invasive transport system for GDNF across the blood-brain barrier. — PubMed · 1997 · Journal Article
- [Identification of macrophage migration inhibitory factor (MIF) in rat spinal cord and its kinetics on experimental spinal cord injury]. — PubMed · 1997 · English Abstract
- [Expression of neurotrophin and IL-1 beta mRNAs following spinal cord injury and the effects of methylprednisolone treatment]. — PubMed · 1997 · English Abstract
- NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord. — PubMed · 1997 · Journal Article
- BDNF prevents and reverses adult rat motor neuron degeneration and induces axonal outgrowth. — PubMed · 1997 · Comparative Study
- Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord. — PubMed · 1997 · Journal Article
- Substance P endopeptidase activity in the rat spinal cord following injury: influence of the new anti-oxidant compound H 290/51. — PubMed · 1997 · Journal Article
- Topical application of insulin like growth factor-1 reduces edema and upregulation of neuronal nitric oxide synthase following trauma to the rat spinal cord. — PubMed · 1997 · Journal Article
- Pretreatment with NMDA receptor antagonist MK801 improves neurophysiological outcome after an acute spinal cord injury. — PubMed · 1996 · Journal Article
- Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma. — PubMed · 1996 · Journal Article
- Spinal endothelin content is elevated after moderate local trauma in the rat to levels associated with locomotor dysfunction after intrathecal injection. — PubMed · 1996 · Journal Article
- Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors. — PubMed · 1996 · Journal Article
- Direct measurement of lipid hydroperoxides in iron-dependent spinal neuronal injury. — PubMed · 1996 · Journal Article
- Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. — PubMed · 1996 · Comparative Study
- Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury. — PubMed · 1995 · Journal Article
- Role of sodium in the pathophysiology of secondary spinal cord injury. — PubMed · 1995 · Journal Article
- Intrathecal dynorphin-A infusion in rat spinal cord causes energy depletion, edema and neurologic dysfunction. — PubMed · 1995 · Journal Article
- Protective effects of antiarrhythmic agents against anoxic injury in CNS white matter. — PubMed · 1995 · Journal Article
- [Interleukin-6 and spinal cord damage in rats]. — PubMed · 1995 · Journal Article
- Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury. — PubMed · 1994 · Journal Article
- Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. — PubMed · 1994 · Journal Article
- Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury. — PubMed · 1994 · Journal Article
- Quantitative MRI of spinal cord injury in a rat model. — PubMed · 1994 · Journal Article
- Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury. — PubMed · 1994 · Journal Article
- Dynamics of extracellular calcium activity following contusion of the rat spinal cord. — PubMed · 1994 · Journal Article
- Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment. — PubMed · 1994 · Journal Article
- Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. — PubMed · 1994 · Comparative Study
- The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum. — PubMed · 1994 · Journal Article
- Effect of U-50488h, a selective opioid kappa receptor agonist, on vascular injury after spinal cord trauma. — PubMed · 1993 · Journal Article
- Halothane anesthesia is neuroprotective in experimental spinal cord injury: early hemodynamic mechanisms of action. — PubMed · 1993 · Comparative Study
- Protective effect of methylprednisolone on vascular injury in rat spinal cord injury. — PubMed · 1992 · Journal Article
- Spinal trauma. Pathophysiology and management of traumatic spinal injuries. — PubMed · 1992 · Journal Article
- The beneficial effects of a thromboxane receptor antagonist on spinal cord perfusion following experimental cord injury. — PubMed · 1992 · Journal Article
- Antioxidant effects in brain and spinal cord injury. — PubMed · 1992 · Journal Article
- Effects of naloxone and nalmefene in rat spinal cord injury induced by the ventral compression technique. — PubMed · 1992 · Comparative Study
- Elevation and clearance of extracellular K+ following contusion of the rat spinal cord. — PubMed · 1991 · Journal Article
- Methylprednisolone treatment of acute spinal cord injury: an introduction. — PubMed · 1991 · Journal Article
- Alteration in extracellular amino acids after traumatic spinal cord injury. — PubMed · 1990 · Journal Article
- Decreases in tissue levels of ubiquinol-9 and -10, ascorbate and alpha-tocopherol following spinal cord impact trauma in rats. — PubMed · 1990 · Journal Article
- Leukotrienes in experimental spinal cord injury. — PubMed · 1989 · Journal Article
- Traumatic spinal cord injury in rats causes increases in tissue thromboxane but not peptidoleukotrienes. — PubMed · 1988 · Journal Article
- Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury. — PubMed · 1988 · Journal Article
- Traumatic injury alters opiate receptor binding in rat spinal cord. — PubMed · 1986 · Journal Article
- Calcium-activated mediators of secondary injury in the spinal cord. — PubMed · 1986 · Journal Article
- Increased dynorphin immunoreactivity in spinal cord after traumatic injury. — PubMed · 1985 · Journal Article
- Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma. — PubMed · 1979 · Journal Article
- Altered blood flow and secondary injury in experimental spinal cord trauma. — PubMed · 1978 · Journal Article
- The effect of antifibrinolytic therapy in experimental spinal cord trauma. — PubMed · 1977 · Journal Article
Indexed as laboratory work
- The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation. — PubMed · 2026 · Journal Article
- 3D Bioprinting for Spinal Cord Injury: Engineering Scaffolds for Functional Recovery. — PubMed · 2026 · Journal Article
- Neuroregenerative and neuroprotective effects of bioengineered scaffolds in spinal cord injury: a systematic review of preclinical and early phase clinical studies. — PubMed · 2025 · Journal Article
- Advancements in Spinal Cord Injury Treatment: Integrating Drug Delivery, Biophysical Stimulation, Cell-Based Therapies, and Tissue Engineering Approaches. — PubMed · 2025 · Journal Article
- Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration. — PubMed · 2025 · Journal Article
- Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway. — PubMed · 2024 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])