A subject this map covers
Gene therapy
What belongs here
Introducing, silencing or editing a gene in nervous-system cells after injury.
What does not belong here, however close it looks
Cells engineered in a dish and then transplanted also belong to cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 185 records · 1992–2026
- Indexed as work in animals: 221 records · 1994–2026
- Indexed as laboratory work: 18 records · 1997–2021
- The source has not said who or what was studied: 99 records · 1997–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
523 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat. — PubMed · 2006 · Comparative Study
- A versatile, low-cost adaptor for stereotaxic and electrophysiologic spinal preparations in juvenile and adult rodents. — PubMed · 2005 · Comparative Study
- Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system. — PubMed · 2005 · Comparative Study
- Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system. — PubMed · 2005 · Journal Article
- Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector. — PubMed · 2005 · Comparative Study
- Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury. — PubMed · 2005 · Journal Article
- Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury. — PubMed · 2005 · Journal Article
- Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia. — PubMed · 2005 · Comparative Study
- BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. — PubMed · 2005 · Journal Article
- Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. — PubMed · 2004 · Journal Article
- Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats. — PubMed · 2004 · Journal Article
- Adenovirus-mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury. — PubMed · 2004 · Journal Article
- Recombinant AAV-mediated gene delivery to the central nervous system. — PubMed · 2004 · Journal Article
- Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord. — PubMed · 2004 · Journal Article
- Cellular transplants: steps toward restoration of function in spinal injured animals. — PubMed · 2004 · Journal Article
- Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. — PubMed · 2003 · Journal Article
- Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. — PubMed · 2003 · Journal Article
- Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. — PubMed · 2003 · Journal Article
- A herpesvirus vector can transduce axotomized brain neurons. — PubMed · 2003 · Journal Article
- Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. — PubMed · 2003 · Journal Article
- Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system. — PubMed · 2002 · Journal Article
- Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. — PubMed · 2002 · Comparative Study
- Repair effect of Schwann cells modified by microgene pSVPoMcat on injured spinal cord in rats. — PubMed · 2002 · Journal Article
- Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. — PubMed · 2002 · Journal Article
- Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. — PubMed · 2002 · Journal Article
- Spinal cord regeneration: from gene to transplants. — PubMed · 2001 · Journal Article
- Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy. — PubMed · 2001 · Journal Article
- [Intraspinal implantation of genetically modified myoblasts with brain-derived neurotrophic factor gene in treating spinal cord injury in rats: neurophysiological study]. — PubMed · 2001 · English Abstract
- Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. — PubMed · 2001 · Journal Article
- Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits. — PubMed · 2000 · Journal Article
- Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1. — PubMed · 2000 · Journal Article
- A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells. — PubMed · 2000 · Journal Article
- Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. — PubMed · 2000 · Journal Article
- Grafting of genetically modified fibroblasts into the injured spinal cord. — PubMed · 2000 · Journal Article
- Single injections of a DNA plasmid that contains the human Bcl-2 gene prevent loss and atrophy of distinct neuronal populations after spinal cord injury in adult rats. — PubMed · 2000 · Journal Article
- Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. — PubMed · 1999 · Journal Article
- A model for long-term transgene expression in spinal cord regeneration studies. — PubMed · 1999 · Journal Article
- Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade. — PubMed · 1998 · Journal Article
- NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats. — PubMed · 1998 · Journal Article
- [Influence of intraspinal implantation of pSVP0MCAT genetically modified Schwann cell in regeneration of injured spinal cord]. — PubMed · 1998 · English Abstract
- Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. — PubMed · 1998 · Journal Article
- Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. — PubMed · 1997 · Journal Article
- Application of recombinant adenovirus for in vivo gene delivery to spinal cord. — PubMed · 1997 · Journal Article
- Ex vivo gene delivery of platelet-derived growth factor increases 0-2A progenitors in adult rat spinal cord. — PubMed · 1996 · Journal Article
- Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. — PubMed · 1995 · Journal Article
- [Spinal cord reconstruction and neural transplants. New therapeutic vectors]. — PubMed · 1994 · English Abstract
Indexed as laboratory work
- Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration. — PubMed · 2021 · Journal Article
- MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. — PubMed · 2017 · Journal Article
- RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth. — PubMed · 2017 · Journal Article
- Therapeutic Use of 3β-[N-(N',N'-Dimethylaminoethane) Carbamoyl] Cholesterol-Modified PLGA Nanospheres as Gene Delivery Vehicles for Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. — PubMed · 2015 · Journal Article
- Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury. — PubMed · 2014 · Journal Article
- Establishment and expression of recombinant human glial cell line-derived neurotrophic factor and TNF α receptor in human neural stem cells. — PubMed · 2012 · Evaluation Study
- Chitosan/TPP-hyaluronic acid nanoparticles: a new vehicle for gene delivery to the spinal cord. — PubMed · 2012 · Journal Article
- Patterned transgene expression in multiple-channel bridges after spinal cord injury. — PubMed · 2010 · Journal Article
- Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. — PubMed · 2009 · Journal Article
- Nanotechnology as an adjunct tool for transplanting engineered cells and tissues. — PubMed · 2007 · Journal Article
- Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. — PubMed · 2007 · Journal Article
- An overview of tissue engineering approaches for management of spinal cord injuries. — PubMed · 2007 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 3660371 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 495 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("gene therapy" OR "gene delivery") - Crossref
spinal cord injury gene therapy gene delivery - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Genetic Therapy"[MeSH Terms] OR "gene therapy"[Title/Abstract] OR "gene delivery"[Title/Abstract])